For example, concentrations of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), platelet factor 4 (PF4) (66), connective tissue-activating peptide III (CTAPIII) and thrombospondin-1 (TSP-1) in platelets were altered depending on the types of cancer (67, 72, 85, 86). This evidence concerns the gene THBS1 and cancer.