Immunomodulatory TNF family members, such as glucocorticoid-induced TNF receptor-related ligand (GITRL) (215), receptor activator of NF-κB ligand (RANKL) and Oxford 40 ligand(OX40L) were upregulated in activated platelets from cancer patients, indicating that they were possibly involved in tumor pathophysiology (216). The gene discussed is TNF; the disease is cancer.