AKT1 and neoplasm: Recently, researchers discovered that chemokine CCL5 and epidermal growth factor (EGF) released by platelets could increase the IL-8 secretion of tumor cells via initiating Akt signaling (163), while platelet-secreted CCL3 engaged its receptor CCR5 on tumor cells to upregulate MMP-1 possibly via the NF-κB pathway.