Interestingly, a new finding denoted that upper tract urothelial carcinoma patients with both high platelet counts and programmed cell death ligand-1 (PD-L1) positivity had shorter metastasis-free survival and overall survival, demonstrating PD-L1 expression might synergize with platelet count in modulating cancer development (21). The gene discussed is CD274; the disease is renal pelvis/ureter urothelial carcinoma.