CD4 and gastric cancer: observed that Modified Bu-zhong-yi-qi decoction suppressed the expression of PD-L1 through blocking PI3K/Akt signaling pathway in gastric cancer, thereby up-regulating the ratio of CD4+/CD8+ T cells and the number of CD8+PD-1+ T cells as well as decreasing the proportion of PD-1+ Tregs induced by chemotherapy, representing as a promising therapy for gastric cancer (76).