YPF suppressed the mRNA levels of immunosuppressive genes in MDSCs, including Arg-1, iNOS and STAT3, and decreased the levels of p-Akt, p-MEK, p-ERK and p-STAT3 to prevent MDSCs augment and induce their apoptosis, which further modulated the proportion of T cell subsets by increasing CD4+/CD8+ T lymphocytes and decreasing Treg proportion, thus reshaping the immune TME and preventing the lung cancer progression (36). The gene discussed is STAT3; the disease is lung cancer.