XIAOPI (XP) formula remarkably prevented the promoting effect of TAMs on the proliferation and self-renewal activity of breast cancer cell lines (MDA-MB-231 and 4T1) in a co-culture system, and reversed the TAMs-mediated C-X-C Motif Chemokine Ligand 1 (CXCL1) secretion and β-catenin signal, thus attenuating the self-renewal activity and chemotherapy resistance of breast cancer stem cells (CSCs). Here, XCL1 is linked to breast cancer.