Recent studies indicated that SLIT2 is frequently inactivated in large B-cell lymphoma (36), lung, breast, colorectal, thyroid (37), gastric (38), and glioma tumors, showing that SLIT2 was a candidate tumor suppressor gene, and recent studies have shown that SLIT2 expression is suppressed or reduced by hypermethylation in the promoter region in various cancers. Here, SLIT2 is linked to central nervous system cancer.