Recent studies indicated that SLIT2 is frequently inactivated in large B-cell lymphoma (36), lung, breast, colorectal, thyroid (37), gastric (38), and glioma tumors, showing that SLIT2 was a candidate tumor suppressor gene, and recent studies have shown that SLIT2 expression is suppressed or reduced by hypermethylation in the promoter region in various cancers. The gene discussed is SLIT2; the disease is neoplasm.