Functional studies indicated LINC00460 can promote proliferation and inhibit apoptosis of CRC cells in vitro and in vivo. Mechanistical studies demonstrated that LINC00460 can be served as a molecular sponge for miR-149-5p, antagonizing its capacity to inhibit cullin 4A (CUL4A) protein translation, which suggests a tumor suppressive role of miR-149-5p, in contrast to the oncogenic function of LINC00460 in CRC (16). Here, LINC00460 is linked to colorectal carcinoma.