CCT3 and breast cancer: Later, Temiz et al. found that in breast cancer, overexpression of miR-149-5p reduces the expression of Chaperonin Containing TCP1 Subunit 3 (CCT3), which leads to the destruction of intracellular reactive oxygen species (ROS) homeostasis and the distribution of free amino acids in energy metabolism, and promotes tumor cell apoptosis (14).