According to previous reports, OTUD6B-AS1 participates in different mechanisms in multiple tumors, such as inhibiting clear cell renal cell carcinoma proliferation via the Wnt/beta-catenin signaling pathway and targeting corresponding miRNAs to act on thyroid carcinoma, bladder cancer, hepatocellular carcinoma, and colorectal carcinoma (24, 26–28). Here, OTUD6B is linked to colorectal carcinoma.