We investigated mRNA expression levels of Cyclin D1, RPTOR, Myc, SMAD3, MARCKS, RICTOR, p16, and FOXM1, which are related to CDK4/6 as, e.g., cellular inhibitor, binding partner, or central proteins of downstream pathways in our 10 cell lines including healthy fibroblasts, breast cancer, and skin cancer cells. The gene discussed is CDK4; the disease is skin cancer.