Our data support that the acting mechanism of SNHG8 could be multiple: (1) it activated BCL-2, preventing GC cells from apoptosis; (2) it activated CCND1, regulating the cell cycle; and (3) it activated CDH1, CDH2Snai1, and VIM, enhancing the epithelial–mesenchymal transition, thus promoting the migration, invasion, and metastasis of GC cells. This evidence concerns the gene VIM and gastric cancer.