This process of BHRF1+/SNHG8 high/miR-512-5p low/TRIM28high in EBVaGC directly enhances the activation of a set of tumor-promoting factors, such as proliferation-related genes (BCL-2, CCND1, PCNA, PARP1) and metastasis-related genes (Snail, VIM, CDH1, and CDH2). The gene discussed is PARP1; the disease is neoplasm.