IDH1 and glioblastoma: GSEA analysis showed that glycolysis, MTORC1, core serum response, proliferation, and E2F signaling pathways were enriched in the C2 subtype of glioblastoma with IDH mutation and IDH wildtype glioblastoma as compared with C1 subtype of glioblastoma with IDH mutation (Figure 4D; P < 0.05).