It has previously been demonstrated that CK1α controls canonical NF-κB activation in stimulated T and in DLBCL cells, participating to the activation of the upstream CBM1 complex (CARD11, BCL10, MALT1), through the phosphorylation of CARD11 and MALT1 (21, 22). The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.