XRCC4 and acute myeloid leukemia: More importantly, in murine AML cells, Runx3 knockdown also significantly reduced the expression of DNA-repair (Chek1, Ddb1, Rad51c, Rpa2, Rpa3, Xrcc1, and Xrcc4) (36.4%, 48.7%, 46.4%, 56.8%, 62.1%, 56.3%, and 28.6% reduction, respectively)- and antiapoptosis (Bcl2, Bcl2l10, Bcl2l12, and Mcl1) (43.3%, 48.5%, 63.3%, and 43.4% reduction, respectively)-related genes that RUNX3 binds to only in AML cells (Figures 5A, B).