More importantly, most of the 5,845 genes specifically bound by RUNX3 in AML cells were related to DNA repair and the negative regulation of apoptosis, such as Chek1, Ddb1, Rad51c, Rpa2, Bcl-2, and Mcl-1(Figures 4E, F). Here, CHEK1 is linked to acute myeloid leukemia.