On the basis of the marker genes (Figure S6A and Table 1), these cell types were defined from cluster 1 to 18 as CD8+ T cells 1, tumor-associated macrophage (TAM) 1, fibroblast, CAF 1, CAF 2, TAM 2, endothelial cells 1, CAF 3, proliferative TAM, monocytes, CAF 4, dendritic cells, pRCC, plasma cells, proliferative T cells, CD8+ T cells 2, endothelial cells 2 and B cells (Figure 1C). This evidence concerns the gene CD8A and neoplasm.