In ccRCC, a total of 12,915 single-cell transcriptome information were acquired from two samples, including 21 different cell types corresponding to ccRCC 1, macrophages 1, ccRCC 2, CD8+ T cells 1, NK cells, endothelial cells 1, TAM, CAF 1, CD4+ T cells, CD8+ T cells 2, FCGR3A+ monocyte, dendritic cells, proliferative fibroblast, endothelial cells 2, ccRCC 3, ccRCC 4, macrophages 2, B cells, mast cells, CAF 2 and CD14+ monocytes (Figure 1D) by the marker genes (Figure S6B and Table 1). Here, CD8A is linked to nonpapillary renal cell carcinoma.