Multivariate analysis confirmed GSTO2-GG variant genotype as an independent poor prognostic factor for DFS (HR = 4.51, 95% CI: 0.81-11.8, p = 0.034) as it conferred greater than fourfold increased relapse risk in B-ALL cases after adjusting other test variables like age, gender, baseline TLC, and ALL risk groups (Table 4). The gene discussed is GSTO2; the disease is acute lymphoblastic leukemia.