PRDX2 and lung cancer: In a lung cancer xenograft model, the treatment of tumors with miR-200c mimic increased cellular radiosensitivity by directly targeting, in addition to the repressor ZEB1, the genes of oxidative stress response sestrin1 (SESN1), NF-related factor 2 (NRF2) and peroxiredoxin 2 (PRDX2), thereby increasing the levels of reactive oxygen species (ROS) (159).