In this study the authors demonstrated that the upregulation of LINC00460 in CRC cell line promotes mutant-p53 expression through competitive binding of miR-149-5p/miR150-5p, and in turn mutant-p53 induces the expression of LINC00460, thus forming a positive feedback loop that drives oxaliplatin resistance in SW480/OxR cells (101). The gene discussed is TP53; the disease is colorectal carcinoma.