CDK4 and non-small cell lung carcinoma: A recent work showed that ectopic expression of miR-34b-3p that is downregulated in non-small-cell lung cancer (NSCLC) tumoral tissue and the cell lines A549 and H1299, represses cell proliferation and cell cycle progression and induces apoptosis of lung cancer cell lines A549 and H1299 by targeting CDK4 kinase, which is important for cell cycle G1 phase progression (32).