(163) found that upregulation of Wnt family member 3A (WNT3A) enhanced the expression of NOTCH3 and its downstream genes, hes family bHLH transcription factor 1 (HES1) and hes related family bHLH transcription factor with YRPW motif like (HEYL), and promoted metastasis of NSCLC. This evidence concerns the gene HES1 and non-small cell lung carcinoma.