CXCR4 and bone metastasis: Univariate analysis suggested that high expression of CXCR4 was significantly correlated with bone metastasis (p=0.004). In addition, it was marginally correlated with brain metastasis (p=0.068) and lymph node metastasis (p=0.085), as well as worse OS (p=0.004) and PFS (p=0.005).