AKT1 and neoplasm: Recent findings indicated that CXCR4 expression on tumor cells plays a positive role in key downstream pathways, including PI3K/AKT/mechanistic target of rapamycin kinase (PI3K/AKT/MTOR) and extracellular signal-regulated kinase 1/2 (ERK1/2), which promote tumor proliferation and migration (149).