Endoplasmic reticulum ribosomal-binding protein 1 (RRBP 1), Glypican1 (GPC1), leucine-rich repeat flightless-1-interacting protein 1 (LRRFIP1), Fibronectin 1 (FN1), or Tensins1 (TNS1), and Nuclear Mitotic Apparatus proteins (NUMA1), were correlated with carcinogenesis and cancer progression via multifaceted methods such as reducing ER stress, as modulators of growth factor signaling, promoting epithelial mesenchymal transition (EMT), participating in cellular adhesion and migration processes, or be involved in deoxyribonucleic acid (DNA) damage repair and homologous recombination et al. This evidence concerns the gene FN1 and cancer.