Despite numerous studies describing a role for TGFβ1 in various neoplasms (22, 31), only two have demonstrated the direct participation of this cytokine in WT, associating TGFβ1 expression in tumor microenvironment invasion and disease progression (32), and showing that TGFβ1 signaling is the most important coordinator of anaplastic histology (33). Here, TGFB1 is linked to neoplasm.