In this article, we will elucidate the inflammatory cascade leading NAFLD to NASH by the TLRs, cytokines, and chemokines, alterations in hepatokines and adiponectin characterizing the inflammatory aspect of NAFLD and leukocyte cell-derived chemotaxin2 (LECTS) and natural killer (NK) cells linked to insulin resistance and form the common morbific insult for type 2 diabetes (T2D) and NASH. This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatohepatitis.