TLR4 and hepatocellular carcinoma: The phagocytosis of saturated fatty acid and cholesterol particles, TLR4 is upregulated and promotes tissue injury, inflammation, fibrosis, and progression to HCC and the obese HCC population has shown evidence of TLR4 messenger RNA (mRNA) with interleukin 6 and interleukin 10 (IL6 and IL10) expression [22,25].