High IL-1β, IL-8, IL-10, TNF-α, tPAI-1, and MCP-1 levels were present in women with MO, and circulating adiponectin was low when compared to NW women. IL-8 was drastically high in women with MO with NAFLD, NASH group, and histologically correlated with hepatic lobular inflammation and ballooning. Here, CXCL8 is linked to metabolic dysfunction-associated steatohepatitis.