GRM5 and schizophrenia: Moreover, in mGluR5 KO mice, there had been impairment of sleep spindle density, enhancement of sleep fragmentation and time spent in NREM sleep, and disruption of NREM sleep-state transitions, among which some phenomena observed were much like the ones in schizophrenia: decreased sleep spindle density and alpha power, and poor 40 Hz visual task-evoked gamma and phase locking [55].