GRM5 and schizophrenia: mGluR5 KO mice showed loss of sleep spindle density, wake alpha power, and 40-Hz visual task-evoked gamma power and phase locking. Also, a reduction in sigma power (10-15Hz) was observed during NREM sleep transitions. Overall, mGluR5 KO mice reproduced those EEG signals much like to schizophrenia patients.