Although its molecular mechanisms have not been explained yet, studies on COVID-19 patient samples had reported the loss of thyroid function (CCND1, MYC, ACTG1 genes in Thyroid hormone signaling pathway with 11.96 fold enrichment and 0.02 p-value, was observed) and related loss of immune system regulation (Lui et al., 2020; Khoo et al., 2021). The gene discussed is ACTG1; the disease is COVID-19.