BBS2 and Down syndrome: However, genes related to other syndromic disorders with a lower prevalence (<1/1,000,000 worldwide), including Alström syndrome (ALSM1; 1–9/1,000,000 [27]), Bardet-Biedl syndrome (ARL6, BBS2, TTC8; only a few reported cases in East Asia [28]), and Jalili syndrome (CNNM4; less than 1/1,000,000 [29]), were likely not present in this relatively small study population.