Our findings suggested that high-risk HCC possessed the increased infiltration levels of activated CD4+ T cell, central memory CD4+ T cell, memory B cell, type 17 helper cell, type 2 helper cell, and activated dendritic cell as well as had the reduced infiltration levels of effector memory CD8+ T cell, CD56 bright natural killer cell, eosinophil, and mast cell. Here, NCAM1 is linked to hepatocellular carcinoma.