Recent studies [14–16] have found that innate immunity is directly involved in the development of gout, and multiple innate immune cells are involved in recognition and phagocytosis of MSU crystals, activation, and signal transduction of intracellular TLR4/NF-κB and regulation of inflammatory cytokines, such as the production and maturation of IL-1β. The gene discussed is IL1B; the disease is gout.