Total glucosides of herbaceous peony (TGPF) can reduce the weight of rats with hyperuricemia nephropathy, reduce serum uric acid (SUA), creatinine (Cr), blood urea nitrogen (BUN), xanthine oxidase (XOD), MCP-1, and TNF-α, downregulate kidney URAT1 and GLUT9, upregulate kidney OAT1, and reduce renal pathology associated with hyperuricemia [92]. The gene discussed is SLC22A12; the disease is hyperuricemia.