The combination of integrin and Tspan8 can act on multiple downstream targets such as ERK, AKT, and JNK, induce tumor angiogenesis by activating the vascular endothelial growth factor signaling pathway, and promote tumor cells to penetrate the vascular endothelial barrier, thereby accelerating tumor cells to metastasize to distant regions [17–19]. Here, VEGFA is linked to neoplasm.