Based on the abovementioned mechanisms of renal injury and renal interstitial fibrosis and the research results of the research group, it is hypothesized that dapagliflozin has the effect of inhibiting alcohol-induced renal injury and reducing renal interstitial fibrosis, possibly by intervening TIMP-1/MMP-24 and so on to play its role in kidney protection. The gene discussed is MMP24; the disease is alcohol dependence.