NLR, PLR, and LMR have a good value for judging RA disease activity, with AUC values of 0.872, 0.821, and 0.824, respectively, indicating that NLR, PLR, and LMR are the same as CRP and ESR and can be used as important indicators in assessing RA disease activity. This evidence concerns the gene ESR1 and rheumatoid arthritis.