With the gradual aging of people, the various immune functions of patients with the myocardial bridge gradually decline, and the incidence of basic diseases such as diabetes and hypertension in patients gradually increases, and insulin resistance may occur in these basic diseases, resulting in an increase in the level of plasminogen activator inhibitor, which in turn increases the serum fibrinogen level, causes blood flow turbulence in microvessels, leads to local microcirculation blockage, and promotes the activation of platelet activating factors, leading to coronary atherosclerosis [13]. This evidence concerns the gene SERPINB2 and coronary atherosclerosis.