To determine whether HER1 SNPs s763317 and rs3752651 and HER2 SNPs rs1058808 and rs1136201 have any association with the age at colorectal cancer diagnosis, colorectal cancer patients were stratified based on the median age at the time of disease diagnosis as ≤58 and > 58 years, and the genotype and allele frequencies were compared to the age-matched controls. The gene discussed is EGFR; the disease is colorectal cancer.