HMGA2 protein, encoded by the HMGA2 gene, has different effects on a number of biological processes, including responses to DNA damage repair, cell cycle, apoptosis, cell senescence, epithelial-mesenchymal transition (EMT), and telomere restoration, so that its aberrant expression in adult tissues is generally associated with both malignant and benign tumor formation [163]. This evidence concerns the gene HMGA2 and benign neoplasm.