In a previous study, newly diagnosed DLBCL patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) were evaluated for their clinical characteristics, therapeutic efficacy and patient survival, and DLBCL patients treated with R-CHOP had better survival than other patients (Hong et al., 2011). This evidence concerns the gene DDIT3 and diffuse large B-cell lymphoma.