TP53 and early-onset autosomal dominant Alzheimer disease: Regarding the progenitor subcategory, the neural stem cell dataset from Smith_hiPSC_MSN_NSC had the largest number of enriched gene gets, with positive enrichment in gene sets such as ribosome, spliceosome, DNA replication, base excision repair, RNA transport, mismatch repair, p53 signaling pathway, and cell cycle, and with negative enrichment in gene sets such as synaptic vesicle cycle, oxidative phosphorylation, Alzheimer disease, and Parkinson disease (Smith-Geater et al., 2020).