Among the 45 key HD genes, the commonly dysregulated genes in mice were Ryr1, Scn4b, Gpr6, Hrh3, Foxp1, Gpr88, Rgs9, Pde10a, Arpp21, Adora 2a, Adcy5, Drd2, Pcp4 (Supplementary Figure S6A). This evidence concerns the gene ADCY5 and Huntington disease.