In this set of most common regulators, we observed regulators such as, SP4, NRF1, BRD4, RYBP, ZFP64, HDAC1, FOXO1, CREB1, NFKB1, BRD2, SP1, CTCF and JUN some of which were previously implicated in HD pathology (De Souza et al., 2016; Dunah et al., 2002; Steffan et al., 2000). The gene discussed is CREB1; the disease is Huntington disease.