SOD1 and amyotrophic lateral sclerosis: SOD1-mutant patients were a subgroup in the overall ALS population, and similar findings could be seen in Japan (62.1 years) (Furuta et al., 2013), Europe (62.1–66.3 years) (Al-Chalabi et al., 2014), and Canada (48.9 years) (Eisen et al., 2008).