Zhang obtained mRNA transcription information and clinical data of gliomas from the TCGA database and found that the expression of RAB42, SHOX2, IGFBP2, HIST1H3G, and IGF2BP3 negatively correlated with 5-years OS; also, IGF2BP3 expression significantly positively correlated with glioma grades (Zhang et al., 2019). This evidence concerns the gene SHOX2 and central nervous system cancer.