TNC and lymphatic malformation: They were CALCRL, TNC, GATA4, CD44, TGM3, CXCL9, CXCL10, PPARG, and NFATC1. CALCRL encodes the membrane receptor CRLR, which is associated with diseases of lymphatic malformation and changes contraction of the vascular smooth muscle resulting in an increase in tissue fluid and thus leads to edema (Dong et al., 2005; Garvey, 2018).