Moreover, studies have revealed that METTL3 and RBM15/15B can modulate m6A modification of lncRNA-XIST, which has been shown to facilitate ccRCC tumorigenicity via the miR-302c/SDC1 axis (Patil et al., 2016; Zhang et al., 2017). This evidence concerns the gene XIST and nonpapillary renal cell carcinoma.