METTL3 and nonpapillary renal cell carcinoma: In contrast, downregulation of METTL3 in endometrial cancer and decreased the expression of alkB homolog 5 (ALKBH5) and fat mass and obesity-associated protein (FTO), which are both “erasers,” in ccRCC, has been suggested to be related to tumorigenicity and dismal prognosis (Liu et al., 2018; Strick et al., 2020).