Yang et al. (2018) found that circRNA FBXW7 suppresses glioma tumorigenesis, Xiong et al. (2019) revealed that circRNA circMAN2B2 mediates glioma progression by regulating S100A8 expression through sponging of miR-1205. Barbagallo et al. (2018) demonstrated that circSMARCA5 affects the migration of glioblastoma multiforme cells by facilitating SRSF1/SRSF3/PTB axis activity. Here, S100A8 is linked to central nervous system cancer.