According to the KEGG analysis, the DEmRNAs targeted by hsa-miR-4512 were significantly enriched in the chemokine signaling, rheumatoid arthritis-associated, NF-kB signaling, and other immune inflammatory pathways (P < 0.05) (Figure 1E), while the DEmRNAs targeted by other candidate miRNAs were not enriched in any immune-related pathways (Supplementary Figure S2). The gene discussed is NFKB1; the disease is rheumatoid arthritis.