Cotransplantation of CD11b+CD11c+ MDSCs in mice reconstituted with STAT6−/− SCs failed to prevent GVHD and 64% of the mice succumbed to the disease, while only 18% of the mice receiving B6-derived WT SCs and CD11b+CD11c+ MDSCs developed lethal GVHD associated with increased GVHD scores (Figures 5A, B). This evidence concerns the gene ITGAX and graft versus host disease.