However, compared to the reconstituted WT recipient mice, irradiated Gsdmd-/- recipient mice receiving WT or Gsdmd-/- bone marrow showed reduced body weight loss (Figure 2A), clinical scores (Figure 2B), histological damage (Figure 2E), and increased colon length (Figures 2C, D), indicating that IECs are critical for the GSDMD-mediated promotion of colitis. Here, GSDMD is linked to colitis.