Studies on the HLA-C locus have been rather few compared to HLA-A and HLA-B, especially when it comes to autoimmunity and self-reactive T cells, with cross-reactive CD8+ T cells from patients with psoriasis targeting peptides of both keratin 17 and streptococcal M-proteins in the context of HLA-C*0602 as a notable exception (24, 25). Here, KRT17 is linked to psoriasis.