Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap has also shown to enhances antitumor efficacy of CAR T cells through attenuating inhibitory T cell signaling, enhancing T cell persistence and expansion, and improving effector function and resistance to exhaustion in a prostate cancer xenograft mouse model (32). Here, TGFB1 is linked to Familial prostate cancer.