In a study, Shum and colleagues have shown that constitutive signaling downstream of IL-7 receptor, through using CD34 ectodomain and endodomain of IL-7Rα (C7R), leads to upregulation of anti-apoptotic protein BCL2 and downregulation of proapoptotic protein CASP8 (Caspase-8) in an orthotopic glioblastoma mouse model (28). This evidence concerns the gene CASP8 and glioblastoma.