In severe disease, however, uniquely upregulated genes associated with increased mitochondrial energetics (genes such as COX4I1/5B/6A1/7A2/8A, ISCU, NDUFA1/A2/B1/B11/B3/UQCR11, SOD1/2, and CFL1), leukocyte degranulation (such as S100A8/A9, cathepsins including CTSD/W and SELP), and coagulation (such as FLNA, ITGA2B, ANXA5, MMRN1, and ANO6), alluding to their role in contributing to the thromboembolic phenotype of severe COVID-19 (Supplementary Figure S4G, Supplementary Table S15). The gene discussed is CTSS; the disease is COVID-19.