Genome-wide association studies (GWAS) and genetic association studies have reported many single nucleotide polymorphisms (SNPs) that were associated with AD pathogenesis, including Toll-like receptors (TLRs), IRF2, IL-4, IL-13, IL-25, IL-31, IL-33, IL1RL1/IL18R1/IL18RAP, STAT6, ORAI1 and TSLP (6–11). Here, IL4 is linked to Alzheimer disease.