The results showed that the anti-IL17A mAb could inhibit N2-phenotype induction in neutrophils mediated by high-dose tumor culture supernatant, while the anti-IFN-γ mAb could induce the transformation of neutrophils from the N1 phenotype to the N2 phenotype (Figures 4F, G and Supplementary Figure S4D). The gene discussed is IFNG; the disease is neoplasm.