Furthermore, the same VEGFR2 treatment was also given to MMTV-PyMT mouse model (Supplementary Figure S2A), a spontaneous breast cancer model, and the low-dose group reduced the primary tumor as well as lung metastasis, while no effect was found in the high-dose group (Figures 1C and Supplementary Figures S2B). This evidence concerns the gene KDR and breast carcinoma.