Although, generating specific mutations found in NFKB1 variant patients using similar approaches would provide a more accurate model of NFKB1 variant induced CVID that might provide further insight, this study indicates an important role for monocytes and macrophages in the immunological phenotype of NFKB1 haploinsufficiency. The gene discussed is NFKB1; the disease is common variable immunodeficiency.