The activated FGFRs regulate the following signaling pathways in the cell through adaptor proteins (64): 1) Rat sarcoma (RAS)-MAPK pathway: fibroblast growth factor receptor substrate 2α (FRS2α) interacts with Crk-like protein (CRKL) and is phosphorylated by FGFRs kinase. Here, CRKL is linked to sarcoma.