Major depressive disorder patients were associated with a significantly smaller increase in oxy-Hb than controls at 12 channels (left ch.4: U = 231.00, p = 0.0032; left ch.6: U = 240.00, p = 0.0050; left ch.7: 256.00, p = 0.0105; left ch.9: U = 175.00, p = 0.0001; left ch.10: U = 227.00, p = 0.0026; left ch.11: U = 217.00, p = 0.0016; left ch.12: U = 216.00, p = 0.0024; left ch.13: U = 244.00, p = 0.0061; left ch.18: U = 264.00, p = 0.0149; left ch.22: U = 239.00, p = 0.0077; right ch.8: U = 209.00, p = 0.0010; and right ch.11 U = 208.00, p = 0.0016). Here, GSTM1 is linked to major depressive disorder.