The top 20 of significant difference signaling pathways are shown in Figure 6C, such as arrhythmogenic right ventricular cardiomyopathy (ARVC), focal adhesion pathway, PI3K-Akt signaling pathway, fatty acid metabolism pathway, ErbB signaling pathway, regulation of actin cytoskeleton, VEGF signaling pathway, FoxO signaling pathway, and others (Figure 6C). The gene discussed is EGFR; the disease is Right ventricular cardiomyopathy.