NF-κβ stimulates the production of pro-inflammatory cytokines, such as TNFα, IL-1β and IL-6 (Li and Verma, 2002; Yamamoto et al., 2003) and have been shown to be elevated in the brains of AD patients and mice models (Jha et al., 2019). The gene discussed is NFKB1; the disease is Alzheimer disease.