In AD, elevated expression of inflammatory mediators includes cytokines, chemokines, prostaglandin E2, nitric oxide (NO), ROS, nuclear factor kappa beta (NF-κβ), macrophage colony-stimulating factor (M-CSF) and MCP-1 were demonstrated around Aβ peptide deposits and neurofibrillary tangles (Akiyama et al., 2000; Morales et al., 2014), suggesting a complex interconnection between neuroinflammation and neurodegeneration. The gene discussed is CCL2; the disease is Alzheimer disease.