Interesting result was obtained by Kester and co-workers (2014) in cross-sectional studies examining the relationship of MRI white matter hyperintensities, lacunes and microbleeds with levels of CSF Aβ42, total tau and tau phosphorylated at threonine 181 (P-tau181) in patients with AD, patients with vascular dementia and control participants. This evidence concerns the gene MAPT and vascular dementia.