APP and Alzheimer disease: Studies in patients resuscitated after cardiac arrest (transient cerebral hypoperfusion) revealed an elevation of Aβ levels in their blood (Zetterberg et al., 2011; Pluta et al., 2021) and an overexpression of APP in their cortical and subcortical neurons (Wiśniewski and Maślińska, 1996), emphasising the significant of hypoxia in the amyloidogenic process of AD.