The levels of NF-κβ p50 and p65 subunits, p-Iκβα/Iκβα, as well as nucleoprotein level of NF-κβ p65 increased significantly in transgenic AD mice exposed to hypoxia, associating the increased pro-inflammatory cytokines and chemokines to activation of NF-κβ pathway (Zhang et al., 2017). This evidence concerns the gene NFKB1 and Alzheimer disease.