PC and type 2 diabetes mellitus: Mitochondrial enzymes, including pyruvate carboxylase (PCX) (fold change: 4.65, p ≤ 0.0001) involved in gluconeogenesis, adiposity, and insulin resistance in type 2 diabetes (Schär et al., 2010), and PCCA (fold change: 3.33, p ≤ 0.0001) (Figure 3B), were also the strong candidates for a PS20 interaction.